The study of pharmacokinetics pk and pharmacodynamics pd in cancer drug discovery and development is often paired and described in reciprocal terms where pk is the analysis of the change in . According to the fda the term population pharmacokinetics poppk is the study of the sources and correlates of variability in drug concentrations among individuals who are the target patient population receiving clinically relevant doses of a drug of interest 243 244 however this definition is very vague poppk involves the analysis of data from a group population of individuals with all their data analyzed simultaneously to provide information about the variability of the . Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management drug development and regulatory issues this expansion has made it difficult for any one individual to become a full fledged expert in all areas fulfilling the need for a wide ranging guide to the many existing subspecialties in this field . Role of pharmacokinetics and metabolism in drug discovery and development role of pharmacokinetics and metabolism in drug discovery and development pharmacol rev 1997 dec494403 49 authors j h lin 1 a y lu affiliation 1 department of drug
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